Pleuromutilins: use in food-producing animals in the European Union, development of resistance and impact on human and animal health.

نویسندگان

  • Engeline van Duijkeren
  • Christina Greko
  • Märit Pringle
  • Keith Edward Baptiste
  • Boudewijn Catry
  • Helen Jukes
  • Miguel A Moreno
  • M Constança Matias Ferreira Pomba
  • Satu Pyörälä
  • Merja Rantala
  • Modestas Ružauskas
  • Pascal Sanders
  • Christopher Teale
  • E John Threlfall
  • Jordi Torren-Edo
  • Karolina Törneke
چکیده

Pleuromutilins (tiamulin and valnemulin) are antimicrobial agents that are used mainly in veterinary medicine, especially for swine and to a lesser extent for poultry and rabbits. In pigs, tiamulin and valnemulin are used to treat swine dysentery, spirochaete-associated diarrhoea, porcine proliferative enteropathy, enzootic pneumonia and other infections where Mycoplasma is involved. There are concerns about the reported increases in the MICs of tiamulin and valnemulin for porcine Brachyspira hyodysenteriae isolates from different European countries, as only a limited number of antimicrobials are available for the treatment of swine dysentery where resistance to these antimicrobials is already common and widespread. The loss of pleuromutilins as effective tools to treat swine dysentery because of further increases in resistance or as a consequence of restrictions would present a considerable threat to pig health, welfare and productivity. In humans, only one product containing pleuromutilins (retapamulin) is authorized currently for topical use; however, products for oral and intravenous administration to humans with serious multidrug-resistant skin infections and respiratory infections, including those caused by methicillin-resistant Staphylococcus aureus (MRSA), are being developed. The objective of this review is to summarize the current knowledge on the usage of pleuromutilins, resistance development and the potential impact of this resistance on animal and human health.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Use of Echinacea purpurea (L.) Moench as an additive in poultry nutrition

Background & Aim: Feed additives have been widely used to stimulate appetite, improve growth performance and immune system function in livestock nutrition. For many years antibiotics have been used in livestock production to improve growth performance. Following the ban on the use of antibiotic growth promoters in animal feeds in European Union and increasing demand for organic...

متن کامل

Use of Echinacea purpurea (L.) Moench as an additive in poultry nutrition

Background & Aim: Feed additives have been widely used to stimulate appetite, improve growth performance and immune system function in livestock nutrition. For many years antibiotics have been used in livestock production to improve growth performance. Following the ban on the use of antibiotic growth promoters in animal feeds in European Union and increasing demand for organic...

متن کامل

European pond turtle (Emys orbicularis persica) as a biomarker of environmental pollution in Golestan and Mazandaran provinces, Iran

Anthropogenic environmental changes are hypothesized as main reasons for animal species population declines. Heavy metals contamination is one of the worst threats to animals among human-caused threats. As most of the heavy metals bioaccumulate in organisms, analyzing concentrations of heavy metals in long living animals, such as turtles, would be very useful for biomonitoring of environmental ...

متن کامل

Pan-European resistance monitoring programmes encompassing food-borne bacteria and target pathogens of food-producing and companion animals.

Antimicrobial resistance is a concern both for animal and human health. Veterinary programmes monitoring resistance of animal and zoonotic pathogens are therefore essential. Various European countries have implemented national surveillance programmes, particularly for zoonotic and commensal bacteria, and the European Food Safety Authority (EFSA) is compiling the data. However, harmonisation is ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • The Journal of antimicrobial chemotherapy

دوره 69 8  شماره 

صفحات  -

تاریخ انتشار 2014